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BioSafe® Multi-Room Cleanroom Designs

BioSafe<sup>®</sup> Cleanroom Illustration   Internal walls create multi-suite facilities that include antechambers and entrance/exit corridors. Versatile HVAC and fan/filter controls allow room-by-room adjustment of air pressure and cleanliness.
BioSafe®: Terra's Ultimate Cleanliness Rating
Terra's BioSafe products meet design and material standards that go far beyond conventional cleanroom requirements.

Developed specifically for aseptic requirements in bio-pharmaceutical cleanrooms, these items incorporate a range of features that minimize particle generation and accumulation and inhibit microbial growth. Learn more . . .
Powder Coated Cleanroom
Multi-room powder-coated BioSafe Cleanroom

Modular panel designs allow complex floor plans and room configurations to meet your workflow requirements.

BioSafe panels function equally well as exterior and interior walls. Their modular design simplifies the engineering of multi-room facilities. The ceiling filtration system is likewise pre-engineered for optimal versatility, allowing rapid configuration of rooms to meet cleanliness standards from ISO 8 to ISO 3 (Class 100,000 to Class 10).

Such features as remote fan/filter control modules and adjustable air return registers allow cascading cleanliness levels and air pressures in multi-room applications. This versatility allows a room to be upgraded to more stringent cleanliness level if required, either by adding additional Fan/Filter Units (FFUs) or ramping up operating speed of existing FFUs from a remote touchscreen control. Rooms with less critical cleanliness requirements operate with fewer FFUs, reducing energy and maintenance expenses. Ceiling-mounted high-volume air handlers can be used to draw air from a production room into a ceiling plenum chamber, creating negative air pressure often required in BSL-2 facilities.

304 Stainless Steel BioSafe Antechamber, shown with solid glass access door and adjacent roll-up door cart pass-through, provides a cleanliness buffer zone for personnel and materials

Antechambers (Airlocks)

Antechambers provide an important buffer zone between rooms with differing cleanliness levels. They are designed to maintain the appropriate air pressure as personnel enter and exit the cleanroom, as well as to limit particle infiltration when a door is opened. Antechambers also provide a convenient staging area for supplies and other materials that are frequently brought into the cleanrooms.

Pass-through chambers also promote clean transfer of materials in and out of the cleanroom. Pass-throughs can be small, wall-mount chambers with interlocked doors, or larger chambers that allow transfer or carts or bulky instruments.


Change Room   Air Shower
Dedicated gowning room, shown in a Stainless Steel BioSafe Cleanroom, linked to ISO 7 and ISO 5 production rooms   Air Shower “washes” personnel with high-velocity HEPA-filtered air to reduce particle load after garmenting

Gowning Room (Change Room)

Insertion of an interior wall adjacent to an antechamber or air shower creates a separate gowning room (change room), where personnel don cleanroom garments, gloves, booties and other apparel.

Typically, a gowning room is designed as a U-shape area, with placement of gowning benches and other furniture reinforcing the proper garmenting protocol to prevent violation of gloves or garments by contaminants that could be carried into the cleanroom (see garmenting protocol). Cleanliness levels in a gowning room are typically not as high as in cleanroom production areas. Placement of an Air Shower between the gowning room and cleanroom helps remove surface contaminants from garbed personnel and reduce the cleanroom particle load.

Entrance corridor   Exit corridor
Entrance corridor links all production rooms and provides a buffer zone between controlled production rooms and uncontrolled warehouse space   Exit corridor of a 304 stainless steel BioSafe Cleanroom also serves as an equipment service corridor
Exit corridor
Exit corridor, with access to electrical service panel
Electrical service panel
Electrical service panel, shown with Power Distribution Module covers removed

Entrance and Exit Corridors

In large, multi-room BioSafe facilities, controlled entrance and exit corridors help to maintain proper air pressure and cleanliness gradients between clean rooms.

Entrance corridors provide an air pressure buffer between the clean rooms and the external environment. Typically, personnel enter this corridor from the gowning room, often by passing through an air shower. Separate antechambers (air locks) link the corridor to each clean room, and adjustable air return registers allow air pressure balancing to maintain the proper differential air pressure between each controlled environment.

Exit corridors provide both a way for personnel to exit the cleanroom and a way to transfer large process equipment into controlled areas. Electrical service panels can also be mounted in the service corridor, allowing servicing of electrical components without breaching the cleanroom environment.

Related BioSafe Pages

BioSafe Panels: Pre-engineered, modular structures provide smooth, easy clean surfaces
Ceiling Grid: including fan/filter units (FFUs), lights, ionizing modules
HVAC and Air Control: including ceiling plenum and ducting system
CleanZone™ Powder Containment Modules: create a pharmaceutical powder containment room
BioSafe Cleanroom Accessories: power and gas connections, sterilization modules, humidity controls and fire safety solutions
BioSafe Pass-Throughs and Air Showers: a complete line of interlocked chambers that prevent contamination during personnel or material transfer
Installation and Certification Services: include 3rd party validation of cleanliness rating, filter integrity, and pressure levels
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