Filtered Gloveboxes
Pharmaceutical Mixing Isolator
This static-dissipative PVC chamber accommodates introduction of drug powders via a hopper interface. A mixing/packaging station is installed inside the low-humidity, static-safe environment, and Ultra-Low Penetration Air (ULPA) filters continuously scrub the process environment to remove potentially hazardous airborne powders. Dual-side air locks allow sample transfer.
Automated nitrogen control system maintains a sub-ambient RH set point down to 5%RH. Ionizing nozzles neutralize static charges to eliminate electro-static discharge (ESD), and static-dissipative chamber eliminates surface charges and the particles they attract, resulting in a clean, static-safe environment for processing sensitive pharmaceutical powders.
Low-Humidity, Easy-Access Isolator
Application Requirements:
- Space-saving corner installation
- Dual pneumatically operated, footswitch-activated access doors
This isolator makes optimal use of corner dead space and accommodates large process equipment. The unique chamber design and dual pneumatic doors put parts within easy reach of gloved operators.
A humidity control system regulates the flow of clean, dry nitrogen into the processing chamber to maintain any user-selected, sub-ambient humidity level. For optimal cleanliness, a closed-loop filtration system draws process gas through a 99.99% efficient HEPA filter; a diverter valve allows 100% recirculation or partial exhausting.
Medical Nano-Fiber Processing Chamber
This containment chamber facilitates evaporation of volatile solvents used in the processing of nano-fibers for medical applications such as organ components, tissue engineering, and drug delivery. Common processes require low humidity (down to 5% RH) in a chamber that must resist corrosive solvents and provide a safe exhaust line for vapor removal. Dry process gas is micro-filtered to remove contaminants.
Pharmaceutical Powder Packaging Glove Box
Application Requirements:
- Particle Control: Open-loop filtration module with dual HEPA filters (@ less than or equal to 4 air changes/minute)
- Access: Right-side pass-through air lock. Glove ports for two operators. Swing-up access window for front loading equipment.
This containment chamber allows safe handling and packaging of chemotherapy powders and other hazardous materials.
A filter/fan unit mounted on the chamber ceiling draws air through a HEPA filter (99.99% efficient @ 0.3µm particles). Exhaust air is drawn through a second HEPA filter and then ventilated through a 4" (102 mm)-diameter conduit to a remote secondary filtration unit. Filter port covers enable the operator to seal the chamber when the filtration system is turned OFF, allowing weighing or handling of fine powders in a still-air, contamination-free environment.
A right-side air lock is provided for passing material in and out of the chamber. In addition, swing-up viewing windows allow convenient front loading of scales, sealers, and other larger processing tools.
Anaerobic Test Chamber
Applications Requirements:
- Extremely Drug-Resistant (XDR) Tuberculosis Therapy Trials
Designed for drug efficacy and dosing studies in anaerobic environments, this automated, dual-level testing chamber maintains an oxygen concentration down to 0.1% at a selected temperature. Computer-controlled electronic interlocks and rapid purging antechambers allow transfer of test samples without disturbing the test environment. These interlocks, in coordination with programmable UV sterilization and HEPA filtration cycles, prevent microbe contamination of the outside environment during sample/equipment extraction.
Other features include touch screen control panel, programmable presets, pneumatic doors leading into the main chamber, rear access panels for large equipment maintenance and end-of-cycle cleaning.
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