ISO 14644-1 is a widely recognized international standard that specifies the classification of air cleanliness in cleanrooms and controlled environments. The standard provides guidance for assessing and controlling the levels of airborne particulates in these environments, which are crucial to industries such as pharmaceuticals, health care, microelectronics, biotechnology and aerospace.
The standard defines cleanrooms as enclosed spaces where the concentration of airborne particles is controlled to meet specific cleanliness requirements. ISO 14644-1 establishes the maximum allowable particle concentration per square meter of air space. The standard also defines the size range of particles considered within the classification, typically diameters of 0.1 micrometers and larger.
In addition to the classification system, ISO 14644-1 provides guidance on monitoring and validating cleanroom conditions, establishing procedures for testing and evaluating air cleanliness, and ensuring ongoing compliance with the specified cleanliness levels.
Terra’s products are designed to comply with the below ISO 14644-1 classifications.
A1 - ISO 4
The maximum allowable concentration in an ISO class 4 environment is 10,000 particles (greater than 0.1 micrometers in diameter) per cubic meter. ISO class 4 cleanrooms, or enclosures, must maintain an average airflow velocity of 50 – 90 feet per minute and an average air change rate of 300 – 540 changes per hour.
A2 - ISO 5
The maximum allowable concentration in an ISO class 5 environment is 100,000 particles (greater than 0.1 micrometers in diameter) per cubic meter. ISO class 5 cleanrooms, or enclosures, must maintain an average airflow velocity of 40 – 80 feet per minute and an average air change rate of 240 – 480 changes per hour.
A3 - ISO 6
The maximum allowable concentration in an ISO class 6 environment is 1,000,000 particles (greater than 0.1 micrometers in diameter) per cubic meter. ISO class 6 cleanrooms, or enclosures, must maintain an average airflow velocity of 25 – 40 feet per minute and an average air change rate of 150 – 240 changes per hour.
A4 - ISO 7
The maximum allowable concentration in an ISO class 7 environment is 352,000 particles (greater than 0.5 micrometers in diameter) per cubic meter. ISO class 7 cleanrooms, or enclosures, must maintain an average airflow velocity of 10 – 15 feet per minute and an average air change rate of 60 – 90 changes per hour.
A4 - ISO 8
The maximum allowable concentration in an ISO class 8 environment is 3,520,000 particles (greater than 0.5 micrometers in diameter) per cubic meter. ISO class 8 cleanrooms, or enclosures, must maintain an average airflow velocity of 1 – 8 feet per minute and an average air change rate of 5 – 48 changes per hour.
Cleanroom Garment Cabinets feature seamless construction that's easy to clean and numerous configurations for various shelves, rods, doors, and hangers. Garment cabinets are further customizable with add-ons including mirrored exteriors, reinforced doors, HEPA filtration, UV sterilization modules, and dissipative materials for electrically sensitive applications.
Cleanroom Cabinet Work Benches are an all-in-one solution that combines cleanroom-grade furniture design with easy cleaning surfaces and cabinets. The base cabinets are suitable for supporting Terra Universal benchtop laminar flow and fume hoods
Plastic Cleanroom Storage Cabinets are available with special features for electronically sensitive components including static dissipative materials and an automatic nitrogen purge system that maintains temperature and humidity.
Stock and Kitting Carts are specially designed to improve organization and maintain ideal conditions for storage of electronic components, reels, wafers, circuit boards, and assembled packages.
Cleanroom Locking Cabinets ensure safe and secure storage for controlled substances, high-value items, or finished goods. Terra offers cabinets with standard lock and key cabinets and add-ons for fingerprint, retinal, and keypad access.
Contamination-Free Plastic Storage Cabinets provide economical, transparent, contamination-free storage cabinets for lab, cleanroom, and stockroom use. Single and dual sided designs to ensure raw stock materials, consumables, and finished products remain organized and easily accessible.
Compare Terra, Metro, and Eagle Storage Systems are available in numerous configurations for general, lab, and cleanroom use. Terra offers shelving systems with a wide selection of materials and shelving layouts. Corrosion-resistant stainless steel and antimicrobial shelving are most popular within labs, healthcare, food processing, and cleanrooms. Chrome shelving is an economical choice for bulk dry storage.
Laminar Flow Transport Carts ensure a continuous HEPA air supply when storing raw or finished products throughout the assembly and handling workflow.
HEPA Mobile Carts with UPS Backup Batteries can power a HEPA integrated blower for up to 120 minutes and recharge via standard wall sockets. Mobile HEPA cabinets are ideal for maintaining ultra-clean air when storage carts must traverse uncontrolled areas or multiple building facilities.
C - Free-Standing Shelving, Storage Racks and Mobile Storage Systems (back to chart)
Optional stands raise equipment to ergonomic height to ease disinfection and sample monitoring. BioSafe design is suitable for any cleanroom or lab environment.
C2 - Benchtop Storage and Shelving
Cleanroom Tool Cabinets are available in a variety of under cabinet, rolling, and benchtop configurations. Terra's durable cleanroom-compatible cabinetry is configurable for storing wafer processing tools, quartz tubes and vessels, injectors, thermocouples, and other critical components.
C3 - Wall-Mounted Cabinets and Storage
Wall-mounted Cleanroom Cabinets and lab storage systems are designed to free up floor space while still being easy to reach. Multiple cabinets can be placed side-by-side to accommodate high throughput.
Intermetro Wall-Mounted Garment Racks are a flexible option for garment or laundry storage. The open wire design promotes laminar airflow and meets ISO 5 cleanroom cleanliness standards.
C4 - Mobile Storage Carts & Racks
Cleanroom Tool Cabinets offer cleanroom-compatible cabinetry for storing wafer processing tools, quartz tubes and vessels, injectors, thermocouples, and other critical components
InterMetro MetroMax i Shelving Systems are a robust commercial storage and shelving solution. The heavy-duty design includes high-capacity polymer shelving, type 304 steel corners, and a lifetime warranty against rust and corrosion. Shelves adjust in 1" increments and feature a built-in Microban antimicrobial coating for maintained cleanliness.
InterMetro MetroMax Q Shelving Systems offer a middle-ground when balancing cost savings with a shelving system that is still durable, clean, and sturdy. MetroMax Q products have all-polymer, epoxy coated shelves and posts with a standard 15-year warranty.
InterMetro Super Erecta Mobile Security Cages feature a double-door front panel that closes and locks to prevent unauthorized access or pilferage. Metro security storage racks offer all of the same flexibility and add-ons synonymous with other wire shelving racks, including modular design, numerous material choices, and many available accessories.
InterMetro Super Erecta Shelving Systems are a highly popular rack and tier wire storage system suitable for both general use in lab or cleanroom environments. The adjustable wire shelves offer industry-leading weight capacity ratings and offer modular compatibility for combining multiple shelving systems. For cleanroom and lab use, stainless steel wire shelves are ideal due to easy cleaning, chemical resistance, and non-corrosive attributes.
Acrylic is an economical, lightweight material. Acrylic is shatterproof and a cost-effective alternative to glass.
D2 - Chrome-Plated Steel Cleanroom Materials
Chrome-plated steel is a highly aesthetic, economical grade material that is well-suited for a wide variety of dry storage and processing areas.
D3 - Polycarbonate Cleanroom Materials
Polycarbonate is transparent with a slight gray tint and offers broad-spectrum chemical resistance, high impact resistance, and excellent thermal resistance (to 200°F / 93.3°C). Polycarbonate is stronger and cracks less easily than both acrylic (15x stronger) and glass (250x stronger).
D4 - Polymer Cleanroom Materials
Polymer storage cabinets offer a strong, lightweight frame design made of chemically-resistant polymer.
D5 - Polypropylene Cleanroom Materials
Polypropylene cabinets offer broad chemical resistance, microbial resistance, and a strong industrial-grade surface.
D6 - Powder-Coated Steel Cleanroom Materials
Terra’s signature white powder coat finish provides a high quality, durable barrier to protect against corrosion, plus a clean and attractive aesthetic. The advanced heat-fused formulation exceeds ASTM and ISO paint standards to resist chipping, scratching, fading, and wearing.
D7 - Static Dissipative PVC Cleanroom Materials
Optional SD-PVC is resistant to common cleaning agents and prevents particle and contaminant aggregation caused by static-cling.
304 Stainless Steel Cabinets feature components that support easy disinfection, wipedown, and sterilization for pharmaceutical and biotechnology use. 304 steel offers better corrosion resistance than galvanized steel or chrome plating, and has reasonable chemical resistance for most applications.
Cabinets with Cleanroom-Grade HEPA Media and Blowers are required to meet or exceed ISO 5 / Class 100 air quality requirements. Terra's HEPA filtration systems are capable of meeting virtually any cleanliness requirements for standards including GMP, IEST, ASTM, and ISO 14644-1.
Optional ULPA filters for ISO 4 (Class 10) cleanroom conditions allow 99.995% particle removal measured at 0.12µm or larger.
HEPA Filter Ovens integrate curing, baking, and drying processes into a passive workflow. Ideal for drying catheters, stents, and other medical devices, ovens with integrated HEPA filters ensure ultra-low
Cabinet Ion Bars reduce the likeness of product damage due to static discharge events or electrostatic particle attraction. Ionizing bars generate a frequency that neutralizes positive and negative ions, therefore subduing polar attraction between ions on objects, in the air, or on surfaces.
ValuLine Mobile Laminar Flow Cabinets are freestanding cabinets with HEPA integrated filtration systems. ValueLine models signal economical material construction while still providing adequate sample protection for most laboratory, cleanroom, and scientific environments. Available with numerous work surfaces and add-ons, Terra's mobile laminar flow cabinets are configurable with integrated ionizers, motorized sashes, particle counters, and ESD-safe materials.
E2 - Humidity Control Storage and Desiccators
The best way to maintain the environment in a desiccator cabinet, glove box, or similar enclosure, is to automatically purge the environment with nitrogen or argon gas.
Terra's IsoDry® Dual Purge System automatically activates a high-flow purge when access doors are opened to ensure fast, effective purging of particles and moisture.
The Smart® Nitro-Watch™ humidity monitoring system includes an improved sensor and controller design that supports built-in data logging, temperature sensing, and USB plug and play.
E3 - Temperature Control Cabinets
Storage Cabinets for Tissue Culture feature adjustable shelves and a spacious interior that accommodates large containers. The polypropylene cleanroom-grade cabinet offers a spacious, secure, and chemically-resistant storage space.
Curing and Drying Cabinets provide a stable climate for a wide variety of microbiology, proteomics, genomics, and agriculture applications.
Terra’s High-Capacity HEPA-Filtered Ovens provide a clean, class 100 environment plus sustained uniform temperature of up to 140° ± 4° F (60° ± 2°C). The easy-to-clean stainless steel design is ideal for sterile applications. Ideal for large items and batch processing operations.
E4 - Static Control Cabinets
Terra's Static Dissipative PVC Cabinets (SDPVC) feature bonded dissipative layers that resist abrasion. SDPVC desiccators retain their surface resistivity of 10^6 - 10^8 ohms/square indefinitely (unlike spray-on coatings that can wear off after a few years), protecting your materials against ESD damage. Further, the control of static charges eliminates particle attractions, helping maintain clean surfaces.
UV Sterilization Cabinets are a popular choice for storing and decontaminating everyday objects or garments; especially porous or electronically sensitive devices that are difficult to clean and easily damaged by water.
Extra Large UV Sterilization Cabinets feature a mirror-finish interior and wire shelving to allow UV exposure on all sides of stored objects. The spacious interior is configurable with hanging racks for storage and disinfection of various frocks, gowns, coveralls, and smocks.
Standard UV Cabinets are designed for batch decontamination of various PPE such as safety glasses, hard hats, face masks/shields.
All-welded 304 stainless steel construction for durability and corrosion-resistance
High-security locking mechanism features two solid steel locking bolts
J4 - Fire-Rated Cabinets and Lab Safes
Fire-Rated Lab Safes feature an internal locking drawer and adjustable shelves for secure and flexible storage. The fireproof design withstands temperatures of up to 1700°F and maintains an internal temperature of 350°F for up to two hours. In addition to a 120-minute fire rating, these sturdy safes can withstand a 30ft drop test.
Double Door Fire and Security Desiccator Cabinets provide low-humidity storage for electronic components while also offering additional protection against theft and fire damage. Security vault desiccator cabinets include all the functionality of standard desiccator cabinets with the additional self-locking doors and keypad entry. The UL-list design is rated for two hours of fire protection.
J5 - Cabinet Ovens - Heated Storage up to 60°C
Terra’s High-Capacity Cabinet Ovens provide a clean, class 100 environment plus sustained uniform temperature of up to 140° ± 4° F (60° ± 2°C). The easy-to-clean stainless steel design is ideal for sterile applications, large items, and batch processing operations during the production of catheters, stents, and medical devices.
Double Sided Passthrough Cabinets allow multiple users to access a storage cabinet from both sides. The double sided design allows quick access and re-stocking of various gowning, storage, and process materials from either side.
Optional drawers are available in either plastic or stainless steel with many sizes and drawer configurations.
K3 - Hanger Rods
Stainless Steel Hanger Rods are preferred for cleanroom use; select chrome-plated for general applications. Cleanroom hanger rods provide a clean and easily accessible storage option for cleanroom garments, gowns, frocks, and coveralls.
Closed loop cleanroom hangers prevent hangers from falling off the rack, while also serving as a security measure to prevent pilferage or damage. Single-piece hanger design minimizes the likeliness of snags and lint generation while cleaning.
Garment Hanger Cabinets are available with or without a center divider. Optional configurations include adjustable shelves, mirrored doors, and combination garment rack/shelves for parallel storage of large and small items.
Divided Garment Cabinets feature a center partition and dual-side doors. Both sides are independently configurable with hangers for garment storage, or shelves for various tools, PPE, and dispensed products.
K4 - Trays
Adjustable, non-contaminating shelves and trays slide on stainless steel racks, allowing easy parts access (one perforated shelf included)
K5 - Casters
Lab and cleanroom chair caster choices range between standard rubber and specialty materials for applications including:
Includes a hanger rod on one side of a divider and storage rack on the other side of the divider for adjustable shelves, ideal for storing other cleanroom tools and materials. Shelves purchased separately.
Did You Know? HEPA/ULPA Filters Do More Than Meet ISO Requirements - they also prevent infection.
Most cleanroom professionals understand that HEPA and ULPA filters capture contaminants that degrade particle-sensitive samples. But they also help remove bacteria, mold spores, and many viruses that contribute to a host of infections.
Most common bacteria are contained by the 0.3-micron pore size of high-efficiency particular air (HEPA) filters. Ultra-Low Penetration Air (ULPA) filters, which are rated 99.999% efficient at retaining particles of 0.12 microns and larger in diameter, capture ultra-fine contaminants, including many large viruses and mold spores.
These filters also remove aerosol-born pathogens - germs that hitch a ride on larger particles and liquid droplets that are captured in a HEPA or ULPA filter. HEPA- or ULPA-based Fan/Filter Units (FFUs) thus can play an important role in infection prevention in surgical theaters, ICUs and other medical settings.
Additionally, HEPA filters can help filter pollen, tiny insects, bacteria, mold, and other fungal spores that might be present during plant tissue culture or cannabis production. Contaminants such as these can find a way in via personnel or normal HVAC units and can blight crops and reduce yields. HEPA Filters help increase crop yields, pass inspection/meet regulations, and reduce contamination.
Here is a list of common human pathogens that HEPA/ULPA filters capture and remove from circulation:
Pathogens: Bacteria and Diseases
SARS-CoV-2: Coronavirus (COVID-19)
Escherichia coli: Gastrointestinal infection
Bacillus anthracis : Anthrax
Aspergillus brasiliensis: Sinus infections
Francisella tularensis: Tularemia
Bordetella pertusis : Whooping cough
Mycoplasma pneumoniae: Pneumonia
Chlamydia pneumoniae: Bronchitis
Clamydia psittaci : Psittacosis
Klebsiella pneumoniae: Opportunistic infections
Haemophilus influenzae : Meningitis
Coxiella burnetii: Q fever
Pseudomonas aeruginosa: Opportunistic infections
Actinomyces israelii: Actinomycosis
Legionella pneumophila: Legionaire's disease
Thermoactinomyces sacchari: Farmer's lung
Alkaligenes: Opportunistic infections
Streptococcus pyogenes: Scarlet fever
Mycobacterium Tuberculosis: Tuberculosis
Powerful UV Sterilization with Safe Operating Features
UV sterilizing cabinets include multiple features for safe operation. A spring-wound timer allows for timing sterilization cycles. A status indicator light confirms unit is operational, and magnetic door kill-switches stop UV operation when either door is open.
Mirror-Finish Interior for 360 Degree Exposure
UV cabinets feature a mirror-finish interior and wire shelving to allow UV exposure on all sides of stored objects. The spacious interior makes it ideal for batch processing various PPE such as safety glasses, hard hats, face masks/shields.
Powerful UV Sterilization with Safe Operating Features
Large UV sterilizing cabinets include a status indicator light to confirm unit is operational, and magnetic door kill-switches to stop UV operation when either door is open.
Mirror-Finish Interior for 360 Degree Exposure
Extra-Large UV sanitizing storage cabinet features a mirror-finish interior to allow UV exposure on all sides. The spacious interior makes it ideal for hanging garments or other tall/long materials.
HEPA-Filtered Cabinet for Contamination-Sensitive Curing, Drying, and Storage
Terra’s Curing and Drying cabinets provide a continuous wash of HEPA filtered air for clean, controlled adhesive curing, PC-board drying, and parts storage. The cabinet can be configured with a motor on both sides to improve horizontal laminar flow. A carbon filter can also be added at the exhaust to capture vapors leaving the cabinet.
Laminar Flow Cabinet Designs
Portable Cleanroom Storage Cabinet with Laminar Air flow
PureFlow™ Laminar Flow Transport Cart, Double Door
UV Sanitizing Cabinet for Nursing Home
Cleanroom Gowning Protocol
ValuLine™ Desiccators from Terra Universal
COVID-19 Contamination Control Products by Terra Universal
ISO-rated portable cleanroom storage cabinet with laminar air flow, 3 chambers, stainless steel | 1529-68 displayedPortable Cleanroom Storage Cabinet with Laminar Air flowTerra’s portable cleanroom storage cabinets are equipped with UL-rated air filtration systems for safe operation. The built-in fan filter unit (FFU) supplies clean ISO 5 or ISO 4 (class 100 or class 10) storage conditions for critical components. An optional power cell allows for mobile operation of the built-in FFU during transportation.
PureFlow Laminar Transport Cart system provides an uninterrupted vertical laminar flow of HEPA-filtered air in the storage area | 1529-68 displayedPureFlow™ Laminar Flow Transport Cart, Double DoorPureFlow Laminar Transport Cart system provides an uninterrupted vertical laminar flow of HEPA-filtered air in the storage area during parts transfer.
UV Sanitizing Cabinet for nursing home to help sterilize everyday high-contact items such has phones, keys, and clothing | 6081-05C displayedUV Sanitizing Cabinet for Nursing HomeUV Sanitizing Cabinet for nursing home to help sterilize everyday high-contact items such has phones, keys, and clothing.
Recommended cleanroom gowning protocolCleanroom Gowning ProtocolVideo demonstration of recommended gowning procedures to avoid violation of clean surfaces in the gowning area or cleanroom and reinforce clean handling protocol.
Designed for purging with nitrogen to achieve low-humidity conditions, each model includes a perforated rear plenum wall that strengthens the cabinet and allowsValuLine™ Desiccators from Terra UniversalDesigned for purging with nitrogen to achieve low-humidity conditions, each model includes a perforated rear plenum wall that strengthens the cabinet and allows gas to enter all chambers uniformly. Doors feature reinforcement ribs to ensure a better seal against closed-cell gasketing. The expansion latches eliminate internal scraping caused by rotary-style latches; the closing mechanism is positioned outside the chamber to keep stored materials clean.
Terra Universal offers an extensive portfolio of COVID-19 contamination control products for employee protection, surface disinfection and product sterilizationCOVID-19 Contamination Control Products by Terra UniversalAs personal and professional lives shift dramatically in response to the COVID-19 pandemic, businesses are searching for methods to reduce the transmission risk of COVID-19 in the workplace. Terra Universal offers an extensive product portfolio to support employee protection, surface disinfection and product sterilization. Let’s take a closer look at two products designed to control the spread of COVID-19.
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