Microbial Contamination Sources in Controlled Environments
Microbial contamination is a significant concern in life science cleanrooms, where maintaining aseptic conditions is critical for the reliability, validity, and safety of personnel and patients in research pursuits.
Microbial contamination can arise from many sources, including spoiled reagents, non-sterile consumables, and improperly disinfected equipment. However, the two main sources of contamination in biomedical and pharmaceutical cleanrooms are airborne microbes and personnel. Microbes present in the air, such as bacteria, fungi, and viruses, can be accidentally introduced into the cleanroom and settle on work surfaces. Cleanroom personnel can unintentionally introduce contaminants into the cleanroom through skin shedding, respiratory droplets, and contact with contaminated surfaces.